Pesquisa | Secretaria de Estado da Saúde

1.

Pharmacological targeting of netrin-1 inhibits EMT in cancer.

Lengrand, Justine; Pastushenko, Ievgenia; Vanuytven, Sebastiaan; Song, Yura; Venet, David; Sarate, Rahul M; Bellina, Melanie; Moers, Virginie; Boinet, Alice; Sifrim, Alejandro; Rama, Nicolas; Ducarouge, Benjamin; Van Herck, Jens; Dubois, Christine; Scozzaro, Samuel; Lemaire, Sophie; Gieskes, Sarah; Bonni, Sophie; Collin, Amandine; Braissand, Nicolas; Allard, Justine; Zindy, Egor; Decaestecker, Christine; Sotiriou, Christos; Salmon, Isabelle; Mehlen, Patrick; Voet, Thierry; Bernet, Agnès; Blanpain, Cédric.

Nature ; 620(7973): 402-408, 2023 Aug.

Artigo Inglês | MEDLINE | ID: mdl-37532929

2.

Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer.

Cassier, Philippe A; Navaridas, Raul; Bellina, Melanie; Rama, Nicolas; Ducarouge, Benjamin; Hernandez-Vargas, Hector; Delord, Jean-Pierre; Lengrand, Justine; Paradisi, Andrea; Fattet, Laurent; Garin, Gwenaële; Gheit, Hanane; Dalban, Cecile; Pastushenko, Ievgenia; Neves, David; Jelin, Remy; Gadot, Nicolas; Braissand, Nicolas; Léon, Sophie; Degletagne, Cyril; Matias-Guiu, Xavier; Devouassoux-Shisheboran, Mojgan; Mery-Lamarche, Eliane; Allard, Justine; Zindy, Egor; Decaestecker, Christine; Salmon, Isabelle; Perol, David; Dolcet, Xavi; Ray-Coquard, Isabelle; Blanpain, Cédric; Bernet, Agnès; Mehlen, Patrick.

Nature ; 620(7973): 409-416, 2023 Aug.

Artigo Inglês | MEDLINE | ID: mdl-37532934

3.

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.

Dominici, Chloé; Moreno-Bravo, Juan Antonio; Puiggros, Sergi Roig; Rappeneau, Quentin; Rama, Nicolas; Vieugue, Pauline; Bernet, Agnes; Mehlen, Patrick; Chédotal, Alain.

Nature ; 545(7654): 350-354, 2017 05 18.

Artigo Inglês | MEDLINE | ID: mdl-28445456

4.

The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.

Guenebeaud, Céline; Goldschneider, David; Castets, Marie; Guix, Catherine; Chazot, Guillaume; Delloye-Bourgeois, Céline; Eisenberg-Lerner, Avital; Shohat, Galit; Zhang, Mingjie; Laudet, Vincent; Kimchi, Adi; Bernet, Agnès; Mehlen, Patrick.

Mol Cell ; 40(6): 863-76, 2010 Dec 22.

Artigo Inglês | MEDLINE | ID: mdl-21172653

5.

DCC constrains tumour progression via its dependence receptor activity.

Castets, Marie; Broutier, Laura; Molin, Yann; Brevet, Marie; Chazot, Guillaume; Gadot, Nicolas; Paquet, Armelle; Mazelin, Laetitia; Jarrosson-Wuilleme, Loraine; Scoazec, Jean-Yves; Bernet, Agnès; Mehlen, Patrick.

Nature ; 482(7386): 534-7, 2011 Dec 11.

Artigo Inglês | MEDLINE | ID: mdl-22158121

6.

Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.

Delloye-Bourgeois, Céline; Gibert, Benjamin; Rama, Nicolas; Delcros, Jean-Guy; Gadot, Nicolas; Scoazec, Jean-Yves; Krauss, Robert; Bernet, Agnès; Mehlen, Patrick.

PLoS Biol ; 11(8): e1001623, 2013.

Artigo Inglês | MEDLINE | ID: mdl-23940460

7.

Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling.

Dudgeon, Crissy; Casabianca, Anthony; Harris, Chris; Ogier, Charline; Bellina, Mélanie; Fiore, Stephany; Bernet, Agnes; Ducarouge, Benjamin; Goldschneider, David; Su, Xiaoyang; Pitarresi, Jason; Hezel, Aram; De, Subhajyoti; Narrow, Wade; Soliman, Fady; Shields, Cory; Vendramini-Costa, Debora Barbosa; Prela, Orjola; Wang, Lan; Astsaturov, Igor; Mehlen, Patrick; Carpizo, Darren R.

Cell Rep ; 42(11): 113369, 2023 11 28.

Artigo Inglês | MEDLINE | ID: mdl-37922311

8.

Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor.

Ducarouge, Benjamin; Redavid, Anna-Rita; Victoor, Camille; Chira, Ruxanda; Fonseca, Aurélien; Hervieu, Maëva; Bergé, Roméo; Lengrand, Justine; Vieugué, Pauline; Neves, David; Goddard, Isabelle; Richaud, Mathieu; Laval, Pierre-Alexandre; Rama, Nicolas; Goldschneider, David; Paradisi, Andrea; Gourdin, Nicolas; Chabaud, Sylvie; Treilleux, Isabelle; Gadot, Nicolas; Ray-Coquard, Isabelle; Depil, Stéphane; Decaudin, Didier; Némati, Fariba; Marangoni, Elisabetta; Mery-Lamarche, Eliane; Génestie, Catherine; Tabone-Eglinger, Séverine; Devouassoux-Shisheboran, Mojgan; Moore, Kathryn J; Gibert, Benjamin; Mehlen, Patrick; Bernet, Agnes.

Cell Death Differ ; 30(10): 2201-2212, 2023 Oct.

Artigo Inglês | MEDLINE | ID: mdl-37633969

9.

Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.

Coissieux, Marie-May; Tomsic, Jerneja; Castets, Marie; Hampel, Heather; Tuupanen, Sari; Andrieu, Nadine; Comeras, Ilene; Drouet, Youenn; Lasset, Christine; Liyanarachchi, Sandya; Mazelin, Laetitia; Puisieux, Alain; Saurin, Jean-Christophe; Scoazec, Jean-Yves; Wang, Qing; Aaltonen, Lauri; Tanner, Stephan M; de la Chapelle, Albert; Bernet, Agnès; Mehlen, Patrick.

Gastroenterology ; 141(6): 2039-46, 2011 Dec.

Artigo Inglês | MEDLINE | ID: mdl-21893118

10.

[Netrin-1, a novel antitumoral target]. / La nétrine-1, une nouvelle cible antitumorale.

Bellina, Mélanie; Bernet, Agnès.

Med Sci (Paris) ; 38(4): 351-358, 2022 Apr.

Artigo Francês | MEDLINE | ID: mdl-35485895

11.

BSA-PEI Nanoparticle Mediated Efficient Delivery of CRISPR/Cas9 into MDA-MB-231 Cells.

Rahimi, Hossein; Zaboli, Kasra Arbabi; Thekkiniath, Jose; Mousavi, Seyed Hossein; Johari, Behrooz; Hashemi, Mohammad Reza; Nosrati, Hamed; Goldschneider, David; Bernet, Agnes; Danafar, Hossein; Kaboli, Saeed.

Mol Biotechnol ; 64(12): 1376-1387, 2022 Dec.

Artigo Inglês | MEDLINE | ID: mdl-35670994

12.

Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer.

Fitamant, Julien; Guenebeaud, Céline; Coissieux, Marie-May; Guix, Catherine; Treilleux, Isabelle; Scoazec, Jean-Yves; Bachelot, Thomas; Bernet, Agnès; Mehlen, Patrick.

Proc Natl Acad Sci U S A ; 105(12): 4850-5, 2008 Mar 25.

Artigo Inglês | MEDLINE | ID: mdl-18353983

13.

Dependence receptors: new targets for cancer therapy.

Brisset, Morgan; Grandin, Mélodie; Bernet, Agnès; Mehlen, Patrick; Hollande, Frédéric.

EMBO Mol Med ; 13(11): e14495, 2021 11 08.

Artigo Inglês | MEDLINE | ID: mdl-34542930

14.

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

Mazelin, Laetitia; Bernet, Agnès; Bonod-Bidaud, Christelle; Pays, Laurent; Arnaud, Ségolène; Gespach, Christian; Bredesen, Dale E; Scoazec, Jean-Yves; Mehlen, Patrick.

Nature ; 431(7004): 80-4, 2004 Sep 02.

Artigo Inglês | MEDLINE | ID: mdl-15343335

15.

NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors.

Paradisi, Andrea; Maisse, Carine; Bernet, Agnès; Coissieux, Marie-May; Maccarrone, Mauro; Scoazec, Jean-Yves; Mehlen, Patrick.

Gastroenterology ; 135(4): 1248-57, 2008 Oct.

Artigo Inglês | MEDLINE | ID: mdl-18692059

16.

[Targeting netrin-1 to inhibit epithelial-mesenchymal transition: a new insight for cancer therapy]. / Cibler la nétrine-1 pour inhiber la transition épithélio-mésenchymateuse - Une nouvelle perspective pour les thérapies anti-cancéreuses.

Braissand, Nicolas; Bernet, Agnès.

Med Sci (Paris) ; 40(2): 124-126, 2024 Feb.

Artigo Francês | MEDLINE | ID: mdl-38411414

17.

Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity.

Sung, Pei-Ju; Rama, Nicolas; Imbach, Jeromine; Fiore, Stephany; Ducarouge, Benjamin; Neves, David; Chen, Huei-Wen; Bernard, David; Yang, Pan-Chyr; Bernet, Agnès; Depil, Stephane; Mehlen, Patrick.

Cancer Res ; 79(14): 3651-3661, 2019 07 15.

Artigo Inglês | MEDLINE | ID: mdl-31088838

18.

Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies.

Bernet, Agnès; Mazelin, Laetitia; Coissieux, Marie-May; Gadot, Nicolas; Ackerman, Susan L; Scoazec, Jean-Yves; Mehlen, Patrick.

Gastroenterology ; 133(6): 1840-8, 2007 Dec.

Artigo Inglês | MEDLINE | ID: mdl-17967459

19.

Netrin PIPes up.

Mehlen, Patrick; Bernet, Agnès.

Nat Cell Biol ; 7(11): 1052-3, 2005 Nov.

Artigo Inglês | MEDLINE | ID: mdl-16385734

20.

Ephrin-B3 supports glioblastoma growth by inhibiting apoptosis induced by the dependence receptor EphA4.

Royet, Amélie; Broutier, Laura; Coissieux, Marie-May; Malleval, Céline; Gadot, Nicolas; Maillet, Denis; Gratadou-Hupon, Lise; Bernet, Agnès; Nony, Pascale; Treilleux, Isabelle; Honnorat, Jérôme; Liebl, Daniel; Pelletier, Laurent; Berger, François; Meyronet, David; Castets, Marie; Mehlen, Patrick.

Oncotarget ; 8(14): 23750-23759, 2017 Apr 04.

Artigo Inglês | MEDLINE | ID: mdl-28423606

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